The local football club 1. FSV Mainz 05 has a long history in the German football leagues. Since 2004 it has competed in the Bundesliga (First German soccer league) except a break in second level in 2007–08 season. Mainz is closely associated with renowned coach Jürgen Klopp, who spent the vast majority of his playing career at the club and was also the manager for seven years, leading the club to Bundesliga football for the first time. After leaving Mainz Klopp went on to win two Bundesliga titles and reaching a Champions League final with Borussia Dortmund. In the summer 2011 the club opened its new stadium called Coface Arena. Further relevant football clubs are TSV Schott Mainz, SV Gonsenheim, Fontana Finthen, FC Fortuna Mombach and FVgg Mombach 03.
The local wrestling club ASV Mainz 1888 is currently in the top division of team wrestling in Germany, the Bundesliga. In 1973, 1977 and 2012 the ASV Mainz 1888 won the German championship.
As a result of the 2008 invasion of Georgia by Russian troops, Mainz acted as a neutral venue for the Georgian Vs Republic of Ireland football game.
The biggest basketball club in the city is the ASC Theresianum Mainz. Its men's team is playing in the Regionalliga and its women's team is playing in the 2.DBBL.
Universitäts-Sportclub Mainz (University Sports Club Mainz) is a German sports club based in Mainz. It was founded on 9 September 1959 by Berno Wischmann primarily for students of the University of Mainz. It is considered one of the most powerful Athletics Sports clubs in Germany. 50 athletes of USC have distinguished themselves in a half-century in club history at Olympic Games, World and European Championships. In particular in the decathlon dominated USC athletes for decades: Already at the European Championships in Budapest in 1966 Mainz won three (Werner von Moltke, Jörg Mattheis and Horst Beyer) all decathlon medals. In the all-time list of the USC, there are nine athletes who have achieved more than 8,000 points – at the head of Siegfried Wentz (8762 points in 1983) and Guido Kratschmer (1980 world record with 8667 points). Most successful athlete of the association is more fighter, sprinter and long jumper Ingrid Becker (Olympic champion in 1968 in the pentathlon and Olympic champion in 1972 in the 4 × 100 Metres Relay and European champion in 1971 in the long jump). Most famous athletes of the present are the sprinter Marion Wagner (world champion in 2001 in the 4 × 100 Metres Relay) and the pole vaulters Carolin Hingst (Eighth of the 2008 Olympics in Beijing) and Anna Battke.
Three world titles adorn the balance of USC Mainz. For the discus thrower Lars Riedel attended (1991 and 1993) and the already mentioned sprinter Marion Wagner (2001). Added to 5 titles at the European Championships, a total of 65 international medals and 260 victories at the German Athletics Championships.
The players of USC's basketball section played from the season 1968/69 to the season 1974/75 in the National Basketball League (BBL) of the German Basketball Federation (DBB). As a finalist to winning the DBB Cup in 1971 USC Mainz played in the 1971–72 FIBA European Cup Winners' Cup against the Italian Cup winners of Fides Napoli.
The Baseball and Softball Club Mainz Athletics is a German baseball and softball club located in the city of Mainz in Rhineland-Palatinate. The Athletics is one of the largest clubs in the Baseball-Bundesliga Süd in terms of membership, claiming to have hundreds of active players. The club has played in the Baseball-Bundesliga for more than two decades, and has won the German Championship in 2007 and 2016.